Thermo Fisher Scientific TPMT Polyclonal Antibody
TPMT 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ICC/IF에 적합. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보유. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length human TPMT (amino acids 1–245) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554013 |
Product Specific Information
- Detects endogenous TPMT protein at approximately 28 kDa.
- Purity >95% by SDS-PAGE.
Target Information
TPMT (Thiopurine S-methyltransferase) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
Defects in TPMT cause thiopurine S-methyltransferase deficiency, affecting drug metabolism.
This enzyme is involved in the inactivation of thiopurine drugs used as immunosuppressants or cytotoxic agents for conditions such as leukemia, autoimmune diseases, and organ transplantation.
Patients with reduced TPMT activity may experience toxicity at standard doses, with genetic variation at the TPMT locus influencing drug response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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