Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), PE
CD8α 단백질을 인식하는 마우스 단클론 항체로, PE로 결합되어 형광 분석에 적합합니다. 닭 세포 반응성이 있으며, Flow Cytometry에 사용됩니다. 565/576 nm 파장에서 여기/방출 특성을 가지며, 4°C에서 암소 보관합니다.
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Applications
- Flow Cytometry (Flow): 0.2 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-8 |
| Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.5, with proprietary stabilizer |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745685 |
Additional Formats
- Unconjugated (MA5-28729)
- APC (MA5-28718)
- Biotin (MA5-28720)
- Cyanine5 (MA5-28722)
- FITC (MA5-28724)
- PE-Cyanine5 (MA5-28727)
- Custom conjugation available upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a key role in T cell signal transduction, differentiation, and activation. CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for major histocompatibility complex class I (MHC-I) molecules.
CD8α is essential for MHC-I binding and can also form homodimers expressed on subsets of T cells, NK cells, monocytes, and dendritic cells. MHC-I/peptide complex ligation recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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