Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), PE

Applications

• Flow Cytometry (Flow): 0.2 µg/10^6 cells

Product Specifications

Additional Formats

• Unconjugated (MA5-28729)
• APC (MA5-28718)
• Biotin (MA5-28720)
• Cyanine5 (MA5-28722)
• FITC (MA5-28724)
• PE-Cyanine5 (MA5-28727)
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a key role in T cell signal transduction, differentiation, and activation. CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for major histocompatibility complex class I (MHC-I) molecules.
CD8α is essential for MHC-I binding and can also form homodimers expressed on subsets of T cells, NK cells, monocytes, and dendritic cells. MHC-I/peptide complex ligation recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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