Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), PE-Cyanine5

Applications

• Flow Cytometry (Flow): 0.1 µg/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• Biotin
• Cyanine5
• FITC
• PE
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays an essential role in signal transduction and T cell activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α and CD8β), functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is critical for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers. Engagement of MHC-I/peptide complexes by antigen-presenting cells recruits Lck kinase, leading to cytokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are vital for pathogen and tumor cell clearance. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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