Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), PE-Cyanine5
CD8α 단백질을 인식하는 마우스 단클론 항체로, Flow Cytometry용 PE-Cyanine5 형광 표지 제품입니다. 조류 및 닭 시료에 반응하며, 세포 표면 CD8 검출과 T세포 활성화 연구에 적합합니다. 4°C 암조건 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 0.1 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-8 |
| Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
| Conjugate | PE-Cyanine5 |
| Excitation / Emission Max | 568 / 666 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.1, with proprietary stabilizer |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745686 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays an essential role in signal transduction and T cell activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α and CD8β), functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is critical for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers. Engagement of MHC-I/peptide complexes by antigen-presenting cells recruits Lck kinase, leading to cytokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are vital for pathogen and tumor cell clearance. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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