Thermo Fisher Scientific CD137 Chimeric Recombinant Rabbit Monoclonal Antibody (BBK4)
인간 CD137을 특이적으로 인식하는 재조합 토끼 단일클론 항체로, HEK293 세포에서 발현됨. Western blot, ICC/IF, Flow cytometry, ELISA 등 다양한 분석에 사용 가능. 단백질 A로 정제되었으며 PBS 완충액에 보관, 연구용으로만 사용.
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Thermo Fisher Scientific CD137 Chimeric Recombinant Rabbit Monoclonal Antibody (BBK4)
Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:1,000 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | Assay-dependent | |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BBK4 |
| Immunogen | The original antibody was raised by immunizing a mouse with human CD137. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for human CD137.
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports survival and clonal expansion of activated and memory CD8+ T cells, while modulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that regulates peripheral monocyte survival. Soluble CD137 may serve as a negative regulatory mechanism for certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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