Thermo Fisher Scientific Tabalumab Chimeric Recombinant Rabbit Monoclonal Antibody (Tabalumab)
Recombinant rabbit monoclonal antibody targeting BAFF, neutralizing both soluble and membrane-bound forms. Suitable for WB, ICC/IF, Flow Cytometry, ELISA, IP, and functional assays. Expressed in HEK293 cells, purified via Protein A, and ideal for autoi...
- 카탈로그번호
- MA551589
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Tabalumab Chimeric Recombinant Rabbit Monoclonal Antibody (Tabalumab)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Neutralization (Neu) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rabbit |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Tabalumab |
| Immunogen | Monoclonal antibodies were generated by immunizing human immunoglobulin transgenic mice with soluble human BAFF (amino acids 133–285). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Tabalumab neutralizes soluble and membrane-bound BAFF, inhibiting BAFF binding to BR3, TACI, and BCMA. Eight transgenic mice producing serum antibody titers to human BAFF were injected intravenously with 10 µg human BAFF in phosphate buffered saline. The spleens were harvested 3 days later and fused with myeloma cells. Twenty hybridomas were tested for specific binding to human BAFF and human immunoglobulin expression via ELISA. The hybridoma producing the antibody that became tabalumab was originally a human IgG1 isotype, later engineered to a human IgG4 isotype for complete BAFF neutralization without depletion of BAFF-expressing cells.
Target Information
Tabalumab has been used in research and clinical trials for autoimmune diseases including rheumatoid arthritis, chronic kidney failure, connective tissue disease, and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.