Thermo Fisher Scientific CD56 Chimeric Recombinant Rabbit Monoclonal Antibody (N901)
CD56 단백질을 인식하는 재조합 토끼 단일클론 항체로, 인간 시료에 반응합니다. ICC/IF, Flow Cytometry, Immunoprecipitation 등에 사용 가능하며, NK 세포 및 신경세포 표지에 유용합니다. 단백질 A로 정제되어 높은 순도와 안정성을 제공합니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | N901 |
| Immunogen | The original antibody was generated by immunizing mice with human chronic myelogenous leukemia (CML) cells. Target: CD56 (NCAM), UniProt ID: P13591-2, Antigen range: 1–858 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds CD56, present on large granular lymphocytes including natural killer cells.
It does not react with monocytes, granulocytes, B cells, erythrocytes, or platelets.
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity.
Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma.
Further, CD56 is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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