Thermo Fisher Scientific ARHGEF11 Polyclonal Antibody
ARHGEF11 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체. Western blot 및 IHC(파라핀)에서 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 순도(>95%) 보유. 인간, 마우스, 랫트 반응성. 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human ARHGEF11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720035 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
ARHGEF11 is a 1527 amino acid protein containing tandem dbl homology and pleckstrin homology domains, a PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence.
It functions as a guanine nucleotide exchange factor (GEF) for RhoA GTPase and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
ARHGEF11 forms complexes with G proteins, regulates Rho-dependent neurite retraction, and increases glutamate transport fourfold by interacting with EAAT4.
It modulates uptake activity and perisynaptic distribution at glutamatergic synapses, induces actin cytoskeleton reorganization, and promotes membrane ruffling and filopodia formation.
ARHGEF11 is ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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