Thermo Fisher Scientific IL-6 Monoclonal Antibody (MQ2-13A5), eBioscience
인간 IL-6를 인식하는 단클론 항체로 ELISA, 유세포분석, 중화 실험 등에 사용 가능. Rat IgG1, kappa 아이소타입의 비결합형 항체. 높은 순도(>90%)와 낮은 응집도(<10%) 보장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | 1 |
| Flow Cytometry (Flow) | - | 7 |
| ELISA | 2–8 µg/mL | 9 |
| Neutralization (Neu) | - | 2 |
| Inhibition Assays (IA) | - | 1 |
| T-Cell Activation (TCA) | - | 1 |
| Miscellaneous PubMed (Misc) | - | 1 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MQ2-13A5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_468426 |
Additional Formats Available
- Alexa Fluor 700 (Cat. 56-7069-42)
- APC (Cat. 17-7069-42)
- eFluor 450 (Cat. 48-7069-42)
- FITC (Cat. 11-7069-82)
- Functional Grade (Cat. 16-7069-81)
- PE (Cat. 12-7069-82)
- PE-Cyanine7 (Cat. 25-7069-42)
- PerCP-eFluor 710 (Cat. 46-7069-42)
- Custom conjugation available upon request
Product Specific Information
The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21–28 kDa cytokine secreted by various cell types.
Applications Reported:
- Capture of human IL-6 by ELISA
- Intracellular staining for flow cytometric analysis
- Neutralization of IL-6 bioactivity
Applications Tested:
This antibody has been tested as the capture antibody in a sandwich ELISA for human IL-6 analysis, in combination with the biotinylated MQ2-39C3 (Cat. 13-7068) antibody for detection and recombinant human IL-6 (Cat. 14-8069) as the standard.
A suitable concentration range for ELISA capture is 2–8 µg/mL.
A standard curve should include doubling dilutions of the recombinant standard from 1000 pg/mL to 8 pg/mL.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-6 (Interleukin-6) encodes a cytokine involved in inflammation and B cell maturation.
It acts as an endogenous pyrogen, inducing fever in autoimmune or infectious conditions.
IL-6 is expressed at sites of acute and chronic inflammation, secreted into serum, and activates inflammatory transcriptional responses via the IL-6 receptor alpha.
It is implicated in multiple inflammation-associated diseases, including diabetes mellitus, systemic juvenile rheumatoid arthritis, Kaposi sarcoma, and rheumatoid arthritis.
Elevated IL-6 levels have been observed in viral infections, including COVID-19 (SARS-CoV-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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