Thermo Fisher Scientific CD6 Monoclonal Antibody (6B9)
Human CD6 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC(P), ELISA에 사용 가능. CD6-ALCAM 상호작용 연구 및 T세포 활성화 관련 연구에 적합. 단백질 G 정제, 액상 형태, 1 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B9 |
| Immunogen | Purified recombinant fragment of human CD6 (amino acids 472–668) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538519 |
Product Specific Information
MA5-17047 targets CD6 in IHC, indirect ELISA, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human CD6 (amino acids 472–668) expressed in E. coli.
MA5-17047 detects CD6 with a predicted molecular weight of approximately 71.8 kDa.
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL).
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated cell adhesion is important for T cell proliferation.
CD6 may exert its functions via association with CD5, possibly fine-tuning CD5 signaling.
Ligation of CD6 has an antiapoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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