Thermo Fisher Scientific Glucagon Monoclonal Antibody (ICACLS), eBioscience
Glucagon 단백질을 인식하는 ICACLS 단클론 항체로, Human, Mouse, Rat에서 반응. IHC 및 파라핀 조직 염색에 적합하며 0.1 µg/mL 이하로 사용 권장. 고순도(>90%) 및 저응집(<10%) 특성. Thermo Fisher Scientific eBioscience에서 제공.
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Thermo Fisher Scientific Glucagon Monoclonal Antibody (ICACLS), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.1 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Fish, Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICACLS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865403 |
Additional Formats
Product Specific Information
This ICACLS monoclonal antibody reacts with human, mouse, and rat glucagon.
Glucagon is a peptide hormone secreted by pancreatic alpha cells within the islets of Langerhans. It acts as an antagonist to insulin, maintaining blood glucose homeostasis through glycogenolysis and gluconeogenesis in the liver.
Secretion is stimulated by hypoglycemia, epinephrine, acetylcholine, and cholecystokinin, and inhibited by insulin and somatostatin. Elevated glucagon levels are associated with pancreatic tumors.
Applications Reported:
Suitable for immunohistochemical staining, including formalin-fixed paraffin-embedded tissue sections.
Applications Tested:
Validated for IHC of formalin-fixed paraffin-embedded human tissue using low pH antigen retrieval. Recommended usage ≤0.1 µg/mL, with careful titration for optimal assay performance.
Purity: Greater than 90%, determined by SDS-PAGE.
Aggregation: Less than 10%, determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Glucagon is a 29-residue polypeptide hormone (MW 3482) produced in the pancreas.
Enteroglucagon (oxyntomodulin), produced in the intestinal mucosa, extends the glucagon sequence by 8 residues at the C-terminus.
Biological activities include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis—antagonistic to insulin action, leading to increased blood glucose levels.
Pancreatic glucagon is localized in alpha cells (15–20% of islet cells), primarily at the islet periphery.
Pathological relevance is linked to glucagon-secreting tumors (glucagonomas).
Glucagon-specific antibodies serve as cell and tumor markers for immunohistochemical and analytical applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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