Thermo Fisher Scientific Phospho-alpha Dystroglycan (Tyr892) Polyclonal Antibody
Phospho-alpha Dystroglycan (Tyr892) 폴리클로날 항체로, 인산화된 DAG1(Tyr892) 특이적 검출. WB 및 IHC(P) 적용 가능. 인간, 마우스, 랫트 반응성. 고순도 정제 및 안정한 PBS/glycerol buffer 보존. 연구용 전용.
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- PA5105944
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DAG1 (Accession Q14118), corresponding to amino acid residues around phosphorylated Tyr892. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817343 |
Product Specific Information
This antibody detects endogenous levels of DAG1 only when phosphorylated at Tyr892.
Target Information
Dystroglycan is a laminin-binding component of the dystrophin-glycoprotein complex, providing linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the mutation site in autosomal recessive muscular dystrophies. Reduced dystroglycan 1 expression in Duchenne muscular dystrophy leads to loss of linkage between sarcolemma and extracellular matrix, increasing susceptibility of muscle fibers to necrosis. It also functions as a dual receptor for agrin and laminin-2 in Schwann cell membranes. Muscle and nonmuscle isoforms differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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