Thermo Fisher Scientific Phospho-Bcl-10 (Ser138) Polyclonal Antibody
BCL10 단백질의 Ser138 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot에 최적화되어 있으며, 인간, 마우스, 랫트 시료에 반응. PBS/glycerol buffer에 보관, -20°C에서 안정적. 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL10 (Accession O95999), corresponding to amino acid residues around phosphorylated Ser138 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817342 |
Product Specific Information
This antibody detects endogenous levels of BCL10 only when phosphorylated at Ser138.
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK.
BCL-10 acts as an adapter protein linking the upstream TNFR1-TRADD-RIP complex to the downstream NIK-IKK-IKAP complex and serves as a substrate for MALT1.
Mutations in the BCL10 gene can lead to Immunodeficiency 37 or mucosa-associated lymphoid type lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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