Thermo Fisher Scientific Phospho-GAB2 (Tyr614) Polyclonal Antibody
GAB2 단백질의 Tyr614 인산화 형태를 특이적으로 인식하는 폴리클로날 항체입니다. Western blot 및 ICC/IF에 사용 가능하며, 사람, 생쥐, 랫트 시료에 반응합니다. 고순도 정제된 액상 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- PA5105940
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GAB2 (Accession Q9UQC2), corresponding to amino acid residues around phosphorylated Tyr614 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817339 |
Product Specific Information
Antibody detects endogenous levels of Gab2 only when phosphorylated at Tyr614.
Target Information
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domains and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high-affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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