Thermo Fisher Scientific Phospho-CD22 (Tyr842) Polyclonal Antibody
Phospho-CD22 (Tyr842) 단백질의 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며 Human, Mouse, Rat 반응성. 고순도 정제, PBS/glycerol buffer에 보존, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD22 (Accession P20273), corresponding to amino acid residues around phosphorylated Tyr842 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817344 |
Product Specific Information
This antibody detects endogenous levels of CD22 only when phosphorylated at Tyr842.
Target Information
CD22 (BL-CAM) is a type 1 integral membrane glycoprotein (130–140 kDa) expressed in both the cytoplasm and cell membrane of B-lymphocytes. It appears early in B-cell differentiation, similar to CD19, and is limited to mature B cells and plasma cells. CD22 expression is strong in hairy cell leukemia and useful for phenotyping mature leukemias. It binds preferentially to α2,6-linked sialic acid, which can be masked by cis interactions. Upon ligand-induced tyrosine phosphorylation, CD22 regulates B-cell receptor signaling through interaction with Src family kinases and inhibitory phosphatases. CD22 is positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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