Thermo Fisher Scientific ATRX Polyclonal Antibody
ATRX 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP 등 다양한 응용에 사용 가능. 인간 ATRX C-말단 영역(2442-2492 aa)을 면역원으로 제작. 액상 형태, 1 mg/mL 농도, 4°C 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 2442 and the C-terminus (residue 2492) of human alpha thalassemia/mental retardation syndrome X-linked (ATRX) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
Target Information
ATRX encodes a protein with an ATPase/helicase domain, belonging to the SWI/SNF family of chromatin remodeling proteins. Mutations in this gene are associated with X-linked mental retardation (XLMR) and alpha-thalassemia (ATRX) syndrome. These mutations can alter DNA methylation patterns, linking chromatin remodeling, DNA methylation, and gene expression during development. The protein undergoes cell cycle-dependent phosphorylation, influencing nuclear matrix and chromatin association, and is implicated in gene regulation and chromosomal segregation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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