Thermo Fisher Scientific STAT5A Monoclonal Antibody (PCRP-STAT5A-1A11)

Applications and Tested Dilution

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/10^6 cells

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody is predicted to work with Mouse and Rat.

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, then form homo- or heterodimers that translocate to the nucleus to act as transcription activators. STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis. In mice, STAT5 alpha induces BCL2L1/BCL-X(L) expression, suggesting anti-apoptotic function. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, with differential accumulation in muscle and mammary tissue. STAT5 alpha is involved in reproduction, lactation, immune function, and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.