Thermo Fisher Scientific mGluR5 Polyclonal Antibody
mGluR5 단백질을 인식하는 Rabbit Polyclonal 항체로 다양한 종에 반응. IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5.6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Chicken, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM5 / MGLUR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550322 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Hamster, Horse, Rabbit, Pig, Turkey, Zebra finch, Chicken, Platypus, Lizard (100%); Xenopus (94%); Opossum, Pufferfish (88%); Zebrafish (82%).For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family.
GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain.
GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 is inhibited by recoverin, a calcium-binding protein.
Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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