Thermo Fisher Scientific mGluR5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

5.6 µg/mL

-

Product Specifications

Species Reactivity

Bat, Bovine, Dog, Chicken, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM5 / MGLUR5. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:mGluR5,uniProtId:P41594-1,ncbiNodeId:9606,antigenRange:1,antigenLength:1212,antigenImageFileName:PA5-32861_mGluR5_P41594-1_Rabbit.svg,antigenImageFileNamePDP:PA5-32861_mGluR5_P41594-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550322

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Hamster, Horse, Rabbit, Pig, Turkey, Zebra finch, Chicken, Platypus, Lizard (100%); Xenopus (94%); Opossum, Pufferfish (88%); Zebrafish (82%).

For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.