Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI1G1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD44 is a 100 kDa type I transmembrane glycoprotein expressed widely on human leukocytes, brain white matter, and various epithelial cells. Multiple isoforms exist, with CD44H being predominant in normal tissues.
It functions as a receptor for hyaluronic acid (HA) and is involved in cell–cell interactions, adhesion, migration, and lymphocyte activation.
CD44 expression can be upregulated in certain carcinomas and may correlate with metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in keratinocytes.
Bone marrow myeloid cells and memory T cells express high levels of CD44, and peripheral B and T cells can upregulate CD44 upon stimulation.
Alternative splicing contributes to the structural and functional diversity of CD44 isoforms.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and it may play a role in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.