Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI1G8), TrueMAB

Applications

• Western Blot (WB): 1:4,000 dilution tested

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, brain white matter, and epithelial cells of the intestine and breast. It serves as a receptor for hyaluronic acid (HA) and plays key roles in:

• Cell-cell interactions
• Cell adhesion and migration
• Lymphocyte activation and homing

CD44 expression is often upregulated in certain carcinomas and may correlate with metastatic potential. Multiple isoforms exist due to complex alternative splicing, contributing to functional diversity.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 is also implicated in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.