Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI1C8), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD44 is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and various epithelial cells. It serves as a receptor for hyaluronic acid (HA) and plays key roles in:

• Cell-cell interactions
• Cell adhesion and migration
• Lymphocyte activation, recirculation, and homing

CD44 expression is often upregulated in certain carcinomas, potentially linked to metastatic potential. It is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells show high CD44 expression, while peripheral B and T cells can upregulate CD44 upon stimulation.

Alternative splicing of CD44 transcripts produces multiple isoforms with distinct functions, contributing to structural and functional diversity. Dysfunction of CD44 is associated with diseases such as superficial keratitis and lichen sclerosus, and may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.