Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI5D5), TrueMAB
CD44 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI5D5). Western blot에 적합하며, Human과 Dog 시료에서 반응. Lyophilized 형태로 제공되며, PBS buffer에 8% trehalose 포함. 세포 부착 및 이동 관련 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:400–1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D5 |
| Immunogen | Full length human recombinant protein of human CD44 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve approximately 1 mg/mL antibody concentration.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, brain white matter, and various epithelial cells. It serves as a receptor for hyaluronic acid (HA) and plays roles in cell adhesion, migration, and lymphocyte activation.
Multiple isoforms exist due to alternative splicing, contributing to structural and functional diversity. CD44 expression is upregulated in certain carcinomas and may be linked to metastatic potential.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 is also implicated in tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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