Thermo Fisher Scientific Human TPO (Thrombopoietin) Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• ELISA: Assay-dependent
• Functional Assay: Assay-dependent
• Control (Ctrl): Assay-dependent

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Product Specifications

Product Specific Information

• Carrier-Free
• Reconstitution:
  • Briefly centrifuge vial before opening.
  • Reconstitute lyophilized recombinant human Thrombopoietin in PBS containing 0.1% human serum albumin.
  • Further dilutions should be made in low endotoxin medium or buffered solution containing carrier protein (e.g., heat-inactivated FCS or tissue culture grade BSA).
• Storage:
  • Store lyophilized preparation at < -20°C, preferably desiccated.
  • After reconstitution, aliquot and store at < -20°C.
  • Avoid repeated freeze/thaw cycles.

Target Information

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) regulates platelet production by acting on hematopoietic cells committed to the megakaryocyte lineage. Binding to its receptor MPL (CD110) activates JAK/STAT, MAPK, and PI3K/AKT signaling pathways, promoting megakaryocyte proliferation and differentiation, ultimately leading to thrombopoiesis.
Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.