Thermo Fisher Scientific Human IRS1 Synthetic Peptide
인간 IRS1 중심부 16개 아미노산 서열을 기반으로 한 합성 펩타이드로, PA5-20137 항체의 블로킹 펩타이드로 사용 가능. 고순도 정제된 액상 형태이며 PBS 완충액에 0.1% BSA 포함. 연구용으로만 사용.
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Thermo Fisher Scientific Human IRS1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the center of human IRS-1.
PEP-0344 can be used as a blocking peptide with polyclonal antibody PA5-20137.
Target Information
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1), and interleukin 4 (IL-4). IRS-1 undergoes phosphorylation on serine, threonine, and tyrosine residues across various tissues.
Casein kinase II, an insulin-sensitive serine/threonine kinase, mediates a portion of the insulin-stimulated phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is the major phosphorylation site catalyzed by casein kinase II in rat IRS-1, and Ser 99 is an additional site.
IRS-1 contains three putative binding sites for 14-3-3 proteins (Ser 270, Ser 374, and Ser 641). The motif around Ser 270 is located within the phosphotyrosine binding domain of IRS-1, responsible for interaction with the insulin receptor.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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