Thermo Fisher Scientific Human NALP2 Synthetic Peptide
인간 NALP2 단백질의 C-말단 12개 아미노산 서열을 기반으로 한 합성 펩타이드. 폴리클로날 항체 PA5-20213의 블로킹 펩타이드로 사용 가능. 염증 및 세포사멸 반응 연구에 적합. 고순도 정제, PBS 버퍼에 0.1% BSA 포함.
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Thermo Fisher Scientific Human NALP2 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 12 amino acids near the carboxy terminus of human NALP2.
PEP-0348 can be used as a blocking peptide with polyclonal antibody PA5-20213.
Target Information
NALP2 belongs to a family of cytoplasmic proteins involved in cellular responses to apoptotic and inflammatory stimuli.
Unlike the prototypical NALP protein NALP1, NALP2 contains a NACHT domain, leucine-rich repeat (LRR), and pyrin-containing domain (PYD).
It interacts with adapter proteins ASC, CARD8, and caspase-1 to form an inflammasome with high proIL-1-b-processing activity.
NALP2 functions as a modulator of NF-kappa-B and procaspase-1 activation in macrophages.
It may act as an innate sensor of pathogens similar to toll-like receptors (TLRs).
At least two alternatively spliced transcript variants encoding distinct isoforms have been identified for NALP2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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