Thermo Fisher Scientific Human NALP2 Synthetic Peptide

Thermo Fisher Scientific Human NALP2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 12 amino acids near the carboxy terminus of human NALP2.
PEP-0348 can be used as a blocking peptide with polyclonal antibody PA5-20213.

Target Information

NALP2 belongs to a family of cytoplasmic proteins involved in cellular responses to apoptotic and inflammatory stimuli.
Unlike the prototypical NALP protein NALP1, NALP2 contains a NACHT domain, leucine-rich repeat (LRR), and pyrin-containing domain (PYD).
It interacts with adapter proteins ASC, CARD8, and caspase-1 to form an inflammasome with high proIL-1-b-processing activity.
NALP2 functions as a modulator of NF-kappa-B and procaspase-1 activation in macrophages.
It may act as an innate sensor of pathogens similar to toll-like receptors (TLRs).
At least two alternatively spliced transcript variants encoding distinct isoforms have been identified for NALP2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.