Thermo Fisher Scientific Human SOCS1 Synthetic Peptide
Human SOCS1 단백질의 N-말단 17개 아미노산 서열을 기반으로 한 합성 펩타이드. 폴리클로날 항체 PA5-20229의 블로킹 펩타이드로 사용 가능. 인간 SOCS1 연구용으로 최적화된 고순도 액상 형태 시약. 연구용으로만 사용.
- 카탈로그번호
- PEP0342
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human SOCS1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the amino terminus of human SOCS1.
PEP-0342 can be used as a blocking peptide with polyclonal antibody PA5-20229.
Target Information
The Suppressor of Cytokine Signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate immune cell responses to cytokines.
SOCS1 suppresses dendritic cell (DC) and T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, which is required for type I and II cytokine receptor signaling. SOCS1 binds directly to the catalytic domain of the kinase and also possesses E3 ubiquitin protein ligase activity, leading to polyubiquitination and degradation of target proteins by the proteasome.
Through this mechanism, SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 via degradation of the TLR signaling adaptor protein TIRAP.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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