Thermo Fisher Scientific Human TOLLIP Synthetic Peptide
인간 TOLLIP 단백질의 C-말단 16개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20204의 블로킹 펩타이드로 사용 가능. PBS 완충액에 0.1% BSA 포함, -20°C 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the carboxy terminus of human TOLLIP.
PEP-0345 can be used as a blocking peptide with polyclonal antibody PA5-20204.
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.
The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF.
TOLLIP associates directly with TLR2 and TLR4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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