Thermo Fisher Scientific Human SOCS1 Synthetic Peptide
휴먼 SOCS1 단백질의 C-말단 15개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20228 항체의 블로킹 펩타이드로 사용 가능. PBS 버퍼(0.1% BSA, 0.02% sodium azide) 용액 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human SOCS1.
PEP-0341 can be used as a blocking peptide with polyclonal antibody PA5-20228.
Target Information
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate immune cell responses to cytokines.
SOCS1 suppresses dendritic cell (DC) and T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, which is required for type I and II cytokine receptor signaling. It binds directly to the catalytic domain of the kinase.
SOCS1 also has E3 ubiquitin protein ligase activity, leading to polyubiquitination and degradation of target proteins via the proteasome. Through this mechanism, SOCS1 negatively regulates Toll-like receptor signaling (TLR2, TLR4) by mediating degradation of the adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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