Thermo Fisher Scientific ARNT2 Polyclonal Antibody
ARNT2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC(Paraffin) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보존되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 20–69 of human ARNT2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553453 |
Product Specific Information
- Detects endogenous ARNT2 protein at approximately 79 kDa.
- Purity >95% by SDS-PAGE.
Target Information
AhR, ARNT1, ARNT2, and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common PAS motif.
The aromatic (aryl) hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that interacts with xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit, and DT-diaphorase.
Ah receptor nuclear translocator proteins (Arnt1 or Arnt2) are required for ligand-dependent nuclear translocation of the Ah receptor and for Ah receptor binding to the XRE element.
BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt3, TIC, JAP3, or MOP-3, can dimerize with Clock and bind to the promoter region of mPer1, indicating a role in regulation of circadian oscillation in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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