Thermo Fisher Scientific CRYBA1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji, mouse fetal eye
• Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (84%), Dog (96%), Rabbit (96%), Chicken (84%), Rhesus Monkey (97%), Bovine (93%), Guinea pig (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class constitutes the major proteins of vertebrate eye lens and maintains lens transparency and refractive index.
Lens central fiber cells lose their nuclei during development, so crystallins are made once and retained throughout life, making them extremely stable proteins.

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins form a superfamily. Alpha and beta families are further divided into acidic and basic groups.
Beta-crystallins differ by the presence of a C-terminal extension (present in basic group, absent in acidic group). They form aggregates of different sizes and can self-associate or heterodimerize with other beta-crystallins.

This gene, a beta acidic group member, encodes two proteins (crystallin beta A3 and beta A1) from a single mRNA. The beta A1 protein is 17 amino acids shorter than beta A3 due to an alternate translation initiation site.
Deletion of exons 3 and 4 causes the autosomal dominant disease zonular cataract with sutural opacities.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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