ELK Biotechnology Stat1 (phospho Tyr701) rabbit pAb
STAT1 (phospho Tyr701) rabbit polyclonal antibody로, 인산화된 STAT1 단백질 검출에 적합합니다. IF, WB, IHC, IP, ELISA 등 다양한 실험에 사용 가능하며, 인간·마우스·랫·원숭이에 반응합니다. -20°C에서 1년간 안정적으로 보관됩니다.
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제품명
Stat1 (phospho Tyr701) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84 |
| Applications | IF; WB; IHC; IP; ELISA |
| Recommended Dilutions | IF: 1:50–200 Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human STAT1 around the phosphorylation site of Tyr701 (AA range: 668–717) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 87 kDa |
| Gene ID (Human) | 6772 |
| Human Swiss-Prot No. | P42224 |
| Cellular Localization | Cytoplasm and nucleus. Translocates into the nucleus upon tyrosine phosphorylation and dimerization in response to IFN-γ and activated FGFR signaling. Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and nuclear translocation. Also translocates into the nucleus in response to interferon-β stimulation. |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, then form homo- or heterodimers that translocate to the nucleus to act as transcription activators. This protein can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. It mediates expression of various genes important for cell viability in response to different stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described (RefSeq, Jul 2008).
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