Thermo Fisher Scientific PKC mu Recombinant Rabbit Monoclonal Antibody (ARC1919)
PKC mu 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot 및 ELISA에 적합하며, 인간, 마우스, 랫트 시료에서 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1919 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 200–300 of human PKC mu (Q15139) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897964 |
Product Specific Information
Positive Samples: HeLa, HT-29, U-87MG, Mouse lung, Mouse testis, Mouse kidney, Rat lung, Rat testis, Rat kidney
Immunogen sequence:
RRRRLSNVSL TGVSTIRTSS AELSTSAPDE PLLQKSPSES FIGREKRSNS QSYIGRPIHL DKILMSKVKV PHTFVIHSYT RPTVCQYCKK LLKGLFRQGL Q
Target Information
The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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