Thermo Fisher Scientific p70S6K Polyclonal Antibody
Human 및 Mouse에서 반응하는 Rabbit Polyclonal 항체로, p70S6K 단백질을 검출. Western blot에 최적화(1:2,500–1:20,000 희석). 항원 친화 크로마토그래피로 정제된 액상 제품이며, 4°C 보관. 성장 인자 신호 및 단백질 합성 연구에 적합.
- 판매단위
- pk
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Thermo Fisher Scientific p70S6K Polyclonal Antibody
Applications
- Western Blot (WB): 1:2,500–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and the C-terminus (residue 525) of human Ribosomal Protein S6 Kinase, 70 kDa, polypeptide 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Rabbit
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein.
p70 S6 kinase is mainly localized in the cytoplasm and plays essential roles in growth factor-regulated cell proliferation, cell motility (including metastasis), immune response, and tissue repair.
It acts downstream of phosphoinositide (PI) 3-kinase, targeting the S6 ribosomal protein to upregulate protein synthesis.
Its kinase activity increases protein synthesis and cell proliferation, and amplification or overexpression of p70 S6 kinase is observed in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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