Thermo Fisher Scientific PDCD1 Monoclonal Antibody (UMAB222), UltraMAB
PDCD1 (PD-1/CD279) 단백질을 인식하는 UMAB222 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot, Flow cytometry, ChIP assay에 사용 가능합니다. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보관됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Flow Cytometry (Flow) | 1:50 | |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB222 |
| Immunogen | Full length human recombinant protein of human PDCD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (also known as PDCD-1) that mediate negative regulatory signals from APCs. PD-1 binds to ligands PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of danger signals such as LPS or other pathogen-associated molecules. PD-1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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