Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (UMAB223), UltraMAB

Applications and Tested Dilution

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for programmed death protein 1 (PD-1). PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by Th2 cytokine IL-4 and to a lesser extent by Th1 cytokines TNF-α and IFN-γ.

PD-L2 has a 2–6 times higher affinity for PD-1 than PD-L1. The PD-1/PD-L1/PD-L2 pathway functions as an inhibitory immune checkpoint, regulating T-cell activation and cytokine secretion. Interestingly, PD-L2 can also stimulate T-cell proliferation and cytokine production independent of PD-1, suggesting additional receptors such as repulsive guidance molecule b (RGMb). PD-L2–RGMb interaction contributes to respiratory tolerance via BMP and neogenin signaling pathways.

The human PD-L2 monomer consists of:

• 201-amino-acid extracellular domain
• 21-amino-acid transmembrane domain
• 32-amino-acid cytoplasmic domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.