Thermo Fisher Scientific DLL3 Recombinant Human Monoclonal Antibody (7B7)
DLL3 단백질을 표적으로 하는 인간 단클론 항체로, Flow Cytometry 및 ELISA에 사용 가능. HEK293 세포에서 발현된 재조합 IgG1 항체이며, 1 mg/mL 농도의 액상 형태로 제공. Notch 신호 경로 연구 및 DLL3 관련 질환 연구에 적합.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1 |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7B7 |
| Immunogen | Recombinant Human DLL3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Wet ice |
| RRID | AB_2912292 |
Product Specific Information
- Antibody tested in Indirect ELISA
Target Information
Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway and inhibits primary neurogenesis. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Defects in DLL3 cause Spondylocostal dysostosis autosomal recessive type 1 (SCDO1), leading to truncal shortening relative to limbs, abdominal protrusion, spinal curvature abnormalities, and sometimes a plagiocephaly-torticollis sequence. DLL3 may be required to divert neurons along a specific differentiation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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