Thermo Fisher Scientific CD100 (SEMA4D) Recombinant Human Monoclonal Antibody (21E8)
인간 CD100(SEMA4D)을 인식하는 재조합 단일클론 항체로, Flow Cytometry 및 ELISA에 적합합니다. HEK293 발현 시스템에서 생산되었으며, IgG4 형식의 비결합 항체입니다. B세포 신호 조절 연구 및 면역학적 분석에 활용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG4 |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 21E8 |
| Immunogen | Recombinant Human SEMA4D protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2912295 |
Product Specific Information
- Antibody tested in Indirect ELISA
Target Information
Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro.
CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down-regulating CD23 expression.
CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells. The protein is weakly expressed on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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