Thermo Fisher Scientific Integrin beta 3 Monoclonal Antibody (BV4)
Integrin beta 3 (CD61) 단백질을 인식하는 BV4 클론의 Mouse Monoclonal Antibody입니다. Western blot, IHC, IP 등 다양한 응용에 사용 가능하며, Human 시료에 반응합니다. PBS + 0.1% BSA 용액 형태로 제공되며, 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BV4 |
| Immunogen | The monoclonal antibody BV4 recognizes human beta3 integrin subunit present in Platelet glycoprotein GPIIb-IIIa (integrin alphaIIb/beta3, CD41/CD61) and in the vitronectin receptor (integrin alphaV/beta3, CD51/CD61). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3091108 |
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and acts as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
It is a 105 kDa glycoprotein that associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface.
CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, and osteoclasts in association with CD51.
Like other integrins, CD61 participates in cell adhesion and cell-surface mediated signaling.
Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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