Thermo Fisher Scientific Leptin Receptor Monoclonal Antibody (2F1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

The monoclonal antibody 2F1 specifically reacts with soluble leptin receptor (sLR) with a molecular mass of approximately 180 kDa. The 2F1 antibody can be used to measure both free sLR and sLR bound to leptin in plasma.

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily and plays an important role in mammalian body weight homeostasis and energy balance. Activation of OB-R by the adipose tissue-secreted hormone leptin triggers downstream signaling via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains, initiating intracellular signaling. Multiple isoforms of OB-R differing in length and signaling capacity exist. The long form of OB-R is expressed in the choroid plexus and hypothalamus, key centers for satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes in mice cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, hyperglycemia, and altered CNS activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.