Thermo Fisher Scientific Macrophages (Mature) Monoclonal Antibody (25F9), Biotin

Applications and Tested Dilution

Product Specifications

Available Formats

• Unconjugated
• FITC
• Request custom conjugation

Product Specific Information

The antibody is associated with fully differentiated tissue macrophages both in normal and diseased tissues, independently of the presence or absence of inflammation. The antigen is absent on freshly isolated monocytes and other blood cells. After 6–7 days of culture, human monocytes become positive. Some melanoma and carcinoma cell lines are also positive. Furthermore, the monoclonal antibody 25F9 cross-reacts with a subpopulation of macrophages of rhesus monkey, pig alveolar macrophages, and Kupffer cells.

Target Information

Macrophages are a type of white blood cell that plays a crucial role in the immune system. They are responsible for detecting, engulfing, and destroying foreign substances such as bacteria, viruses, dead cells, and debris. Mature macrophages are found in various tissues throughout the body and are specialized to perform specific functions depending on their location. For example:

• Alveolar macrophages: found in the lungs, remove inhaled foreign particles.
• Kupffer cells: found in the liver, remove old or damaged red blood cells.

Understanding macrophage function is essential for developing new treatments for cancer, autoimmune disorders, and infections.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.