Thermo Fisher Scientific CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), APC, eBioscience

Thermo Fisher Scientific CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), APC, eBioscience™

Applications

• Flow Cytometry (Flow): Tested dilution 5 µL (0.125 µg)/test
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• Miscellaneous PubMed (Misc): –
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Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 532
• Alexa Fluor 700
• APC-eFluor 780
• Biotin
• Brilliant UV 737
• Brilliant Violet 650
• eFluor 450
• FITC
• NovaFluor Blue 660-120S
• NovaFluor Blue 690
• NovaFluor Red 700 / 725 / 755
• NovaFluor Yellow 610 / 700
• PE, PE-Cyanine5.5, PE-Cyanine7
• Super Bright 436 / 600 / 702
• Request custom conjugation available

Product Specific Information

The eBio124-1D1 monoclonal antibody reacts with human CD7 (gp40, Leu9), a 40 kDa receptor belonging to the immunoglobulin gene superfamily.
CD7 is expressed on most immature and mature T lymphocytes, T cell leukemias, NK cells, and a subset of B cells. Cross-linking CD7 modulates T cell and NK activity through calcium flux, adhesion molecule expression, cytokine secretion, and proliferation. CD7 associates directly with phosphoinositol 3-kinase, inducing D-3 phosphoinositides and tyrosine phosphorylation.

A clonogenic subpopulation of CD34(+) CD38(-) cord blood cells expressing CD7 shows lymphopoietic capacity, generating B cells, NK cells, and dendritic cells.
CD7 also cooperates with CD28 in Treg function; deficiency in both reduces Treg numbers and suppressive activity.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells.
Use at 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD7 (gp40, Leu9) is a 40 kDa immunoglobulin superfamily member expressed on immature and mature T lymphocytes, T cell leukemias, NK cells, and subsets of B cells.
It modulates T and NK cell activity and serves as an important marker in leukemia diagnostics.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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