Thermo Fisher Scientific FBXO8 Monoclonal Antibody (OTI11F6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The FBXO8 gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif.
F-box proteins are part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
They are divided into three classes:

• Fbws: Contain WD-40 domains
• Fbls: Contain leucine-rich repeats
• Fbxs: Contain other protein-protein interaction modules or no recognizable motifs

FBXO8 belongs to the Fbxs class and includes a C-terminal sequence similar to yeast Sec7p, a regulator of vesicular protein transport.
This protein may interact with ADP-ribosylation factors (ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.