Thermo Fisher Scientific CD3e Monoclonal Antibody (FN-18), FITC

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: View 17 publications

Miscellaneous PubMed (Misc)

• Publications: View 9 publications

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• Request custom conjugation

Product Specific Information

Reconstitution

• Dissolve vial contents in 0.5 mL sterile distilled water.
• Lyophilized product is stable for at least one year at 4°C, protected from light.
• After reconstitution, store at 4°C for one month (protected from light).
• For long-term storage, aliquot and store at -20°C (protected from light) for up to one year.
• Add 0.02% sodium azide to prevent bacterial growth.

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into T cells and regulating TCR complex expression. CD3 subunits (gamma, delta, epsilon, zeta) are structurally related immunoglobulin superfamily members encoded on human chromosome 11. These subunits have long cytoplasmic tails that interact with signal transduction molecules via tyrosine-based motifs. CD3 is expressed on 68–82% of peripheral blood lymphocytes and 65–85% of thymocytes, but not on B or NK cells. Altered CD3 expression may be observed in autoimmune diseases. Defects in CD3 genes are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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