Thermo Fisher Scientific CD3e Monoclonal Antibody (FN-18), Biotin

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: View 5 publications

Miscellaneous PubMed (Misc)

• Publications: View 2 publications

Product Specifications

Additional Formats

• Unconjugated
• FITC
• Request custom conjugation

Product Specific Information

• Reconstitution: Dissolve the contents of the vial by injection of 0.5 mL sterile distilled water.
• Stability: Lyophilized product is stable for at least one year at 4°C. After reconstitution, store at 4°C for one month or at -20°C for one year.
• Preservation: Add 0.02% sodium azide to prevent bacterial growth.

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating surface expression of the TCR complex.
Activation through the TCR involves CD3 gamma, delta, epsilon, and zeta subunits, which are members of the immunoglobulin superfamily encoded on chromosome 11.
These subunits have long cytoplasmic tails that associate with signal transduction molecules through a double tyrosine-based motif.
CD3 is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Decreased T lymphocyte percentages may be observed in autoimmune diseases.
Defects in CD3 genes are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.