Thermo Fisher Scientific Phospho-AKT (Thr308) Monoclonal Antibody (18F3.H11)

Thermo Fisher Scientific Phospho-AKT (Thr308) Monoclonal Antibody (18F3.H11)

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• DyLight 488
• DyLight 549
• DyLight 649
• Request custom conjugation available

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge if not clear after standing at room temperature.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.
• Specific for human and mouse AKT protein phosphorylated at T308.
• BLAST analysis suggests cross-reactivity with AKT pT308 from most vertebrate species based on 100% homology with the immunizing sequence.
• Cross-reactivity with AKT2 and AKT3 likely occurs.

Target Information

AKT1 (PKB alpha) is a serine/threonine kinase regulating cell survival. It inhibits apoptosis and promotes cell cycle progression by phosphorylating multiple targets. Activated by insulin, PI3K, IGF1, and other growth factors, Akt inactivates apoptosis-related proteins such as forkhead transcription factors and caspase-9. The AKT pathway is a key target for cancer drug discovery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.