Thermo Fisher Scientific HSP27 Monoclonal Antibody (G3.1)
HSP27 단백질을 특이적으로 인식하는 Mouse IgG1 단일클론 항체. Western blot, ELISA, IP 등 다양한 응용에 적합. Human 시료에 반응하며, 단백질 A로 정제된 액상 형태로 제공. -20°C에서 안정적으로 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000–1:50,000
Immunoprecipitation (IP)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G3.1 |
| Immunogen | Produced by repeated immunizations with a prokaryotic recombinant protein corresponding to the full-length human HSP27 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.5M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
Reacts specifically with HSP27 in human tissues and cell lines. MCF-7 cells are recommended as a positive control.
Cross-reactivity with HSP27 from other mammalian sources is likely.
No cross-reactivity occurs with HSP70, HSP90, or HSP104.
Target Information
In response to environmental stress, cells increase expression of heat shock proteins.
HSPB1 (heat shock protein beta-1 or HSP27) is a small molecular chaperone that maintains denatured proteins in a folding-competent state.
It contributes to stress resistance and actin organization, and regulates phosphorylation and axonal transport of neurofilament proteins.
Mutations in the HSPB1 gene can result in Charcot-Marie-Tooth disease 2F and distal hereditary motor neuronopathy type 2B.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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