Thermo Fisher Scientific beta Amyloid Polyclonal Antibody
Rabbit polyclonal antibody recognizing beta Amyloid for WB and ICC/IF applications. Detects ~120 kDa band in brain lysates. Suitable for multiple species. Supplied as liquid, 1 mg/mL, stored at -20°C. For research use only.
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- PA112527
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 653–662 (isoform APP751) of human Amyloid Precursor Protein (APP) or 1–10 of the 4 kDa beta Amyloid peptide generated by beta- and gamma-secretases |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070388 |
Product Specific Information
This antibody is predicted to react with rabbit, pig, bovine, guinea pig, and chicken based on sequence homology.
In Western blot, this antibody detects a ~120 kDa band in human, mouse, and rat brain tissue lysates.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
- Beta-secretase (BACE) cleaves the extracellular, amino-terminal domain of beta APP.
- Gamma-secretase then cleaves the membrane-bound remnant to generate the amyloid beta peptide.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2, along with nicastrin, which modulates beta APP processing. Abeta forms extracellular filamentous protein components of amyloid cores and neuritic plaques, also found in neurofibrillary tangles.
Beta amyloid deposits are associated with:
- Alzheimer’s disease
- Lewy body dementia
- Down’s syndrome
- Cerebral amyloid angiopathy
- Amyloidosis (Dutch type)
- Guam Parkinson-Dementia complex
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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