Thermo Fisher Scientific MORF Polyclonal Antibody
MORF 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot에 최적화되어 있으며, 고순도(>95%)로 정제된 제품입니다. 연구용으로만 사용되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human KAT6B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553909 |
Product Specific Information
This antibody detects endogenous MORF protein at a molecular weight of approximately 231 kDa.
Purity is >95% by SDS-PAGE.
Target Information
MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) involved in chromatin remodeling and transcription regulation. The MOZ gene was originally identified in acute myeloid leukemia subtypes with MOZ fusion proteins, which enhance transcriptional activation through aberrant histone acetylation.
MORF (MOZ-related factor) and Tip60 share significant similarities with MOZ, including the putative HAT domain. MORF possesses both a transcriptional repression domain at its N-terminus and a potent activation domain at its C-terminus, suggesting dual roles in transcriptional regulation. Tip60, initially identified as a coactivator for the HIV TAT protein, also functions as a nuclear hormone receptor coactivator enhancing ligand-dependent steroid receptor-mediated transactivation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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