Thermo Fisher Scientific MORF Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:1,000
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Product Specifications

Product Specific Information

This antibody detects endogenous MORF protein at a molecular weight of approximately 231 kDa.
Purity is >95% by SDS-PAGE.

Target Information

MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) involved in chromatin remodeling and transcription regulation. The MOZ gene was originally identified in acute myeloid leukemia subtypes with MOZ fusion proteins, which enhance transcriptional activation through aberrant histone acetylation.

MORF (MOZ-related factor) and Tip60 share significant similarities with MOZ, including the putative HAT domain. MORF possesses both a transcriptional repression domain at its N-terminus and a potent activation domain at its C-terminus, suggesting dual roles in transcriptional regulation. Tip60, initially identified as a coactivator for the HIV TAT protein, also functions as a nuclear hormone receptor coactivator enhancing ligand-dependent steroid receptor-mediated transactivation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.