Thermo Fisher Scientific Desmoglein 2 Monoclonal Antibody (CSTEM28), eBioscience

Applications and Tested Dilution

Product Specifications

Available Formats

• Alexa Fluor 488
• PE
• Request custom conjugation

Product Specific Information

The CSTEM28 monoclonal antibody reacts with human desmoglein 2 (DSG2), a type 1 transmembrane protein of the cadherin family. DSG2 is expressed by epithelial cells, cardiomyocytes, endothelial progenitors, and CD34⁺CD45^dim hematopoietic stem and progenitor cells. It forms desmosomes, providing tensile strength to tissues under mechanical stress.

Beyond desmosome formation, DSG2 is involved in barrier integrity, adhesion, migration, apoptosis, proliferation, vasculogenic mimicry, and intracellular signaling. DSG2-expressing endothelial progenitor cells are pro-angiogenic, implicating DSG2 in vascular formation. In hematopoietic cells, DSG2 expression is highest in CD38⁻CD90⁺ multipotent cells and decreases with differentiation, being absent in mature lymphocytes. DSG2 also serves as a receptor for adenoviruses and may be shed by mucosal barriers in the intestine.

This antibody has been validated by:

• Flow cytometric analysis of the 2102ep cell line
• Immunocytochemistry of fixed and permeabilized cells (≤10 µg/mL recommended)

Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered

Target Information

Desmosomes are cell-cell junctions present in epithelial, myocardial, and certain other cell types. Three desmoglein subfamily members have been identified, all part of the cadherin superfamily. The desmoglein gene cluster resides on chromosome 18. DSG2 is also known as the autoantigen in pemphigus vulgaris, an autoimmune skin blistering disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.