Thermo Fisher Scientific c-Jun Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-833 detects c-Jun from mouse cells.
PA1-833 has been successfully used in Western blot and ChIP procedures.
By Western blot, this antibody detects an ~40 kDa protein representing c-Jun in NIH 3T3 serum-stimulated cells.
A smaller band is also detected at ~26 kDa, possibly representing a proteolytic fragment of c-Jun.

The PA1-833 immunogen is a synthetic peptide corresponding to residues T(91) P T P T Q F L C P K N V T D(105) of mouse c-Jun.
Reconstitute in 200 µL PBS to create a stock of 1 mg/mL.

Target Information

c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
It promotes activity of NR5A1 when phosphorylated by HIPK3, leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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