Thermo Fisher Scientific Phospho-ALK/p80 (Tyr1282, Tyr1283) Polyclonal Antibody
ALK/p80 단백질의 Tyr1282, Tyr1283 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide epitope around sequence YRAS-YYRKG corresponding to ALK/p80 with phosphorylation at Tyr1282 and Tyr1283 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long term, store at −20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Positive Control: Not specified
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often generate fusion genes, notably NPM-ALK, which exhibits oncogenic properties. ALK encodes a receptor tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK. ALK plays a crucial role in neuronal development and signaling within the nervous system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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